Dr Sue Crosthwaite

Senior Group Leader- Circadian Biology
Department:Genetics, Genomics & Breeding
Tel:01732 843833

Research Interests

My interest lies in understanding how organisms sense and respond to their environment. Over the last 20 years I have studied the molecular basis of circadian rhythmicity utilizing the model organism Neurospora crassa.  The circadian clocks that drive rhythmicity are endogenous timekeepers that enable organisms to prepare for predictable changes in environmental conditions. Changes in gene expression orchestrated by such clocks result in the adaptation of an organism’s cellular biochemistry, physiology and behaviour to a given temporal niche.  Currently my focus is the role of clock genes in the vascular wilt Verticillium dahliae and the role played by circadian clocks in determining plant-pathogen interactions.  I also have a keen interest in RNA biology and recent work has focused on non-protein coding RNAs and RNA splicing.

Selected Publications

  • Xue, Z., Ye, Q., Anson, S.R., Yang, J., Xiao, G., Kowbel, D., Glass, N.L., Crosthwaite, S.K., Liu, Y. . (2014). Transcriptional interference by antisense RNA is required for circadian clock function Nature. 514. 650-653.
  • Arthanari, Y., Heintzen, C., Griffiths-Jones, S. and S.K. Crosthwaite.. (2014). Natural Antisense Transcripts and Long Non-Coding transcripts in Neurospora crassa PLoS ONE e91353..  doi: 10.1371.
  • Tseng, Y-Y. , Hunt, S. M., Heintzen, C., Crosthwaite, S. K. *and J-M, Schwartz* [* these authors contributed equally to this work] . (2012). Comprehensive modelling of the Neurospora circadian clock and its temperature compensation PLOS Comp Biol. doi:10.1371/journal.pcbi.1002437..
  • Chen, D., Vollmar, M., Rossi, M.N., Phillips, C., Kraehenbuehl, R., Slade, D., Mehrotra, P.V., von Delft, F., Crosthwaite, S.K., Gileadi, O., Denu, J.M. and I. Ahel. . (2011). Identification of macro- domain proteins as novel O-acetyl-ADP-ribose deacetylases.  J Biol Chem. 286, . 13261-13271.
  • Lee, H-C., Li, L., Gu, W., Xue, Z., Crosthwaite, S.K., Pertsemlidis, A., Lewis, Z. A., Freitag, M., Selker, E. U., Mello C. C. and Y. Liu . (2010). Diverse Pathways Generate MicroRNA-like RNAs and Dicer-Independent Small Interfering RNAs in Fungi. Mol. Cell. 38. 803-814.