Dr Helen Bates
My background is in using molecular biology, protein purification, interaction and characterisation to study DNA replication and repair and plant RNA virus replication. I have worked with many different systems including plants, plant RNA viruses, Drosophila, plant fungal pathogens and E.coli.
My current areas of research are focused on using DNA and RNA sequencing technologies to investigate plants and plant pathogen interactions. I have developed the nanopore sequencing facilities at NIAB EMR enabling us to achieve very long read sequencing of plant, fungal and insect genomes. I am also interested in investigating protein:DNA interactions to look at control of gene expression.
Staff Recent Research Projects
Current projects I am involved in are sequencing of the octoploid strawberry genome, using Illumina and Nanopore sequencing technologies to identify Fusarium oxysporum at the sub-species level from soil samples, developing techniques to investigate protein:DNA interactions for the Verticillium Clock and Mycoprotein projects using EMSA and ChIPseq.
- Hulin MT, Armitage AD, Vicente JG, Holub EB, Baxter L, Bates HJ, Mansfield JW, Jackson RW, Harrison RJ. (2018). Comparative genomics of Pseudomonas syringae reveals convergent gene gain and loss associated with specialization onto cherry (Prunus avium). New Phytologist, doi: 10.1111/nph.15182.
- Fan, R., Cockerton, H.M., Armitage, A.D., Bate, H., Cascant-Lopez, E., Antanaviciute, L.. (2018). Vegetative compatibility groups partition variation in the virulence of Verticillium dahlia on strawberry. PLoS One. 13(2), e0191824.
- Andrew D Armitage, Andrew Taylor, Maria K Sobczyk, Laura Baxter, Bethany P.J. Greenfield, Helen Bates, Fiona Wilson, Alison Jackson, Sascha Ott, Richard Harrison, John P. Clarkson. (2018). Pangenomic analysis reveals pathogen-specific regions and novel effector candidates in Fusarium oxysporum f.sp.cepae. (preprint) BioRxiv. doi: https//doi.org/10.1101/182238.
- Gilles Crevel, Helen Bates, Hella Guikeshoven, Sue Cotterill. (2001). The Drosophilia Dpit47 protein is a nuclear Hsp90 co-chaperone that interacts with DNA polymerase alpha. Journal of Cell Science. 114(pt 11):2015-25.
- Andre Mathe, Helen Bates, Hella Huikeshoven, Peter Deak, David Glover, Sue Cotterill. (2000). Importin-α3 Is Required at Multiple Stages of Drosophila Development and Has a Role in the Completion of Oogenesis. Developmental Biology. 223(2):307-22.
- Helen Bates, Toba Osman, Mariam Farjah, K.W. Buck . (1995). Isolation and characterization of an RNA-dependent RNA polymerase from Nicotiana clevelandii plants infected with red clover necrotic mosaic dianthovirus. Journal of General Virology. 76 (pt 6)(6):1483-91.